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Tg(Dbh-cre/ERT2)198.1Hroh
Transgene Detail
Summary
Symbol: Tg(Dbh-cre/ERT2)198.1Hroh
Name: transgene insertion 198.1, Hermann Rohrer
MGI ID: MGI:4821735
Synonyms: DBHCreERT2, DBH-CT198.1
Transgene: Tg(Dbh-cre/ERT2)198.1Hroh  Location: unknown  
Alliance: Tg(Dbh-cre/ERT2)198.1Hroh page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Dbh-cre/ERT2)198.1Hroh expression driven by 1 gene
 
Mutation details: A cre-ERT2 cassette with a polyA sequence was inserted into a BAC containing the mouse Dbh gene by homologous recombination, resulting in cre expression directed by the Dbh promoter. This construct was integrated into the C57BL/6 background. Cre induction by tamoxifen in mice crossed to a reporter line exhibited cre activity in noradrenergic cells (sympathetic ganglia, adrenal chromaffin cells, and the locus ceruleus). (J:163233, J:180731)
Generation of Tg(Dbh-cre/ERT2)198.1Hroh.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dbh (mouse)
Summary of all recombinase alleles driven by Dbh.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:163233 Tsarovina K, et al., The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci. 2010 Aug 11;30(32):10833-43
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory