Cyp1a1tm4.1Dwn
Targeted Allele Detail
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| Symbol: |
Cyp1a1tm4.1Dwn |
| Name: |
cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 4.1, Daniel W Nebert |
| MGI ID: |
MGI:4830524 |
| Synonyms: |
Cyp1a1mtp |
| Gene: |
Cyp1a1 Location: Chr9:57595211-57611107 bp, + strand Genetic Position: Chr9, 31.34 cM
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| Alliance: |
Cyp1a1tm4.1Dwn page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:163973
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 2 was replaced with a modified exon 2 in which nucleotide substitutions (CTT to AAT at codon 7 and CTC to AAC at codon 17) result in the amino acid substitutions of asparagine for leucine at positions 7 and 17 (L7N and L17N) in the SRP-binding and ER transmembrane anchor/stop transfer sequence. A floxed neo cassette inserted upstream of the modified exon was removed by cre mediated recombination. The product is predicted to undergo mitochondrial proteolysis targeting.
(J:163973)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cyp1a1 Mutation: |
39 strains or lines available
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| Original: |
J:163973 Dong H, et al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Mol Pharmacol. 2009 Mar;75(3):555-67 |
| All: |
1 reference(s) |
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Analysis Tools
