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Tg(MMTV-cre)105Ayn
Transgene Detail
Summary
Symbol: Tg(MMTV-cre)105Ayn
Name: transgene insertion 105, Alexander Yu Nikitin
MGI ID: MGI:4837133
Synonyms: MMTV-Cre
Transgene: Tg(MMTV-cre)105Ayn  Location: unknown  
Alliance: Tg(MMTV-cre)105Ayn page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(MMTV-cre)105Ayn expression driven by 1 gene
 
Mutation details1.48 kb of the mouse mammary tumor virus (MMTV) long terminal repeat drives mammary epithelium-specific expression of cre. The cre expression cassette is followed by several introns of methallothionein-I (MT-I) and its polyadenylation sequence. Five lines (104A, 105, 106, 107, and 108) were generated. Cre expression in line 105 is restricted to the mammary gland. (J:165292)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: MMTV (virus)
Summary of all recombinase alleles driven by MMTV.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:165292 Cheng L, et al., Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene. 2010 Oct 21;29(42):5700-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory