Cyp2a5<tm1Ding> Targeted Allele Detail MGI Mouse (MGI:4837923)

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Cyp2a5^tm1Ding
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cyp2a5^tm1Ding
Name:	cytochrome P450, family 2, subfamily a, polypeptide 5; targeted mutation 1, Xinxin Ding
MGI ID:	MGI:4837923
Synonyms:	Cyp2a5-null
Gene:	Cyp2a5 Location: Chr7:26534764-26542689 bp, + strand Genetic Position: Chr7, 15.54 cM
Alliance:	Cyp2a5^tm1Ding page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:165695
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 9 was replaced with a loxP site flanked neomycin resistance gene cassette. The absence of transcript expression was confirmed by RT-PCR on olfactory mucosa, liver, lung, kidney, and testis extracts. (J:165695)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cyp2a5 Mutation:	35 strains or lines available

References

Original:	J:165695 Zhou X, et al., Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther. 2010 Feb;332(2):578-87
All:	13 reference(s)

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