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Rims2tm1Sse
Targeted Allele Detail
Summary
Symbol: Rims2tm1Sse
Name: regulating synaptic membrane exocytosis 2; targeted mutation 1, Susumu Seino
MGI ID: MGI:4838195
Synonyms: Rim2alpha-
Gene: Rims2  Location: Chr15:39061681-39547768 bp, + strand  Genetic Position: Chr15, 15.45 cM, cytoband C
Alliance: Rims2tm1Sse page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163080
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 4 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on islet cell extracts. (J:163080)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rims2 Mutation:  250 strains or lines available
References
Original:  J:163080 Yasuda T, et al., Rim2alpha determines docking and priming States in insulin granule exocytosis. Cell Metab. 2010 Aug 4;12(2):117-29
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory