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Ssttm2.1(cre)Zjh
Targeted Allele Detail
Summary
Symbol: Ssttm2.1(cre)Zjh
Name: somatostatin; targeted mutation 2.1, Z Josh Huang
MGI ID: MGI:4838416
Synonyms: SOM-iCre, SOM-IRES-Cre, SSTCre, Sst-iCre, Sst-IRES-Cre
Gene: Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Alliance: Ssttm2.1(cre)Zjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151755
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Project Collection: Neuroscience Blueprint cre
Mutation
description
Allele Type:    Targeted (Knockdown, Recombinase)
Mutation:    Insertion
 
Ssttm2.1(cre)Zjh expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the somatostatin locus (Sst). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. This mutation results in a dosage-dependent knock-down of endogenous Sst expression J:279254 . (J:151755)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sst (mouse)
Summary of all recombinase alleles driven by Sst.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Sst Mutation:  37 strains or lines available
References
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  591 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory