Med12<tm1Hsch> Targeted Allele Detail MGI Mouse (MGI:4839484)

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Med12^tm1Hsch
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Med12^tm1Hsch
Name:	mediator complex subunit 12; targeted mutation 1, Heinrich Schrewe
MGI ID:	MGI:4839484
Synonyms:	Med12^hypo
Gene:	Med12 Location: ChrX:100317636-100341071 bp, + strand Genetic Position: ChrX, 43.91 cM, cytoband C2
Alliance:	Med12^tm1Hsch page

Mutation
origin

Mouse Generated:	Earliest citation of chimera generation: J:166040
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Mutation
description

Allele Type:		Targeted
Mutation:		Insertion
		Mutation details: One loxP site was inserted in the 5'UTR of exon 1 while a second loxP site, followed by an FRT flanked neomycin cassette in reverse orientation, was inserted in intron 7. Gene expression was reduced 90%. (J:166040)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Med12 Mutation:	6 strains or lines available

References

Original:	J:166040 Rocha PP, et al., Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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