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Bco2tm1Dnp
Targeted Allele Detail
Summary
Symbol: Bco2tm1Dnp
Name: beta-carotene oxygenase 2; targeted mutation 1, Adrian Wyss
MGI ID: MGI:4840382
Gene: Bco2  Location: Chr9:50444387-50466481 bp, - strand  Genetic Position: Chr9, 27.74 cM, cytoband B
Alliance: Bco2tm1Dnp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ and neo cassette replaced exons 1 through 4 and part of exon 5. The absence of protein expression was confirmed by western blot analysis on hepatocyte cellular extracts. (J:170742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bco2 Mutation:  25 strains or lines available
References
Original:  J:166153 Ford NA, et al., Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr. 2010 Dec;140(12):2134-8
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory