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Cebpatm1.1(cre)Touw
Targeted Allele Detail
Summary
Symbol: Cebpatm1.1(cre)Touw
Name: CCAAT/enhancer binding protein alpha; targeted mutation 1.1, Ivo P Touw
MGI ID: MGI:4867437
Synonyms: CebpaCre
Gene: Cebpa  Location: Chr7:34818718-34821353 bp, + strand  Genetic Position: Chr7, 21.02 cM
Alliance: Cebpatm1.1(cre)Touw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166620
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Cebpatm1.1(cre)Touw expression driven by 1 gene
 
Mutation details: A 14.4 kb targeting vector containing the cre recombinase sequence and an Frt-flanked puromycin selectable marker was used to insert cre after the initiation codon of Cebpa, replacing the single Cebpa exon. Correctly targeted 129/Sv/C57BL/6 ES cells were injected into B6 blastocysts to generate chimeras. The chimeras were crossed to FLPeR mice to remove the puromycin cassette. (J:166620)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cebpa (mouse)
Summary of all recombinase alleles driven by Cebpa.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  19 strains or lines available
References
Original:  J:166620 Wolfler A, et al., Lineage-instructive function of C/EBPalpha in multipotent hematopoietic cells and early thymic progenitors. Blood. 2010 Nov 18;116(20):4116-25
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory