Calb2<tm2.1(cre/ERT2)Zjh> Targeted Allele Detail MGI Mouse (MGI:4880758)

Calb2^{tm2.1(cre/ERT2)Zjh}
Targeted Allele Detail

Summary

Symbol:	Calb2^{tm2.1(cre/ERT2)Zjh}
Name:	calbindin 2; targeted mutation 2.1, Z Josh Huang
MGI ID:	MGI:4880758
Synonyms:	Calb2-CreER-KI , Calb2-CreERT2-KI, Calb2-CreERT2-KI, Calretinin-CreER-KI, CR-CreER-KI, CR-CreERT2-KI
Gene:	Calb2 Location: Chr8:110869158-110894844 bp, - strand Genetic Position: Chr8, 57.44 cM
Alliance:	Calb2^{tm2.1(cre/ERT2)Zjh} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:151755
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6
Project Collection:	Neuroscience Blueprint cre

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Calb2^{tm2.1(cre/ERT2)Zjh} expression driven by 1 gene

Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene, an SV40 polyA signal, and anFRT-flanked neo cassette into the initiation codon of the Calb2 (calbindin 2; also called calretinin or CR) locus. This construct was electroporated into C57BL/6-derived embryonic stem (ES) cells. Mutant mice were bred with Actin-FLPe mice to remove the neo cassette, (J:151755)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Calb2 (mouse) Summary of all recombinase alleles driven by Calb2. Comparative matrix view of recombinase activities Alliance mouse Calb2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Calb2 Mutation:	23 strains or lines available

References

Original:	J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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