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Ofd1tm2.1Bfra
Targeted Allele Detail
Summary
Symbol: Ofd1tm2.1Bfra
Name: OFD1, centriole and centriolar satellite protein; targeted mutation 2.1, Brunella Franco
MGI ID: MGI:4882077
Synonyms: Ofd1fl
Gene: Ofd1  Location: ChrX:165173029-165223700 bp, - strand  Genetic Position: ChrX, 77.28 cM
Alliance: Ofd1tm2.1Bfra page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106035
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exons 4 and 5 were flanked by loxP sites via homologous recombination. The FRT flanked neo cassette was removed by flp-mediated recombination. This allele was used to generate Ofd1tm1Bfra. (J:106035)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 83 assay results
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ofd1 Mutation:  14 strains or lines available
References
Original:  J:106035 Ferrante MI, et al., Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet. 2006 Jan;38(1):112-7
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory