Tg(Mlana-cre)5Bee
Transgene Detail
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| Symbol: |
Tg(Mlana-cre)5Bee |
| Name: |
transgene insertion 5, Friedrich Beermann |
| MGI ID: |
MGI:4887843 |
| Synonyms: |
MART1-cre, MART-1::Cre |
| Transgene: |
Tg(Mlana-cre)5Bee Location: unknown
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| Alliance: |
Tg(Mlana-cre)5Bee page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Mlana-cre)5Bee expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Mlana (MGI:108454) |
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Mutation details: BAC clone RP23-308B16 was modified by recombineering methods so that a cre-polyA cassette with an FRT-ampicillin-FRT selection cassette replaced the start codon of Mlana (MART-1). Cre expression is controlled by the Mlana (MART-1) regulatory sequences. The targeting construct was electorporated into bacterial cells for homologous recombination and selection, followed by induction of Flp-mediated excision of the ampicillin cassette. The BAC construct was injected into fertilized oocytes and 5 founder lines, 4 of which showed reporter expression in pigment cells when crossed to ROSA26-R mice. Line 5 was propagated for futher analysis.
(J:172135)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Mlana
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:172135 Aydin IT, et al., A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium. Genesis. 2011 May;49(5):403-9 |
| All: |
6 reference(s) |
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Analysis Tools
