Tg(Lck-cre)19Hhan
Transgene Detail
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| Symbol: |
Tg(Lck-cre)19Hhan |
| Name: |
transgene insertion 19, Hua Han |
| MGI ID: |
MGI:4889049 |
| Synonyms: |
Lck-Cre, LckCre |
| Transgene: |
Tg(Lck-cre)19Hhan Location: unknown
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| Alliance: |
Tg(Lck-cre)19Hhan page
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| Strain of Origin: |
(DBA x C57BL/6)F1
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Lck-cre)19Hhan expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Lck |
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Mutation details: The cre recombinase sequence was fused to a nuclear localization signal and inserted between the Lck promoter and the 3' untranslated fragment of the human beta-globin gene in the transgene. The construct was microinjected into male pronuclei of fertilized oocytes. Animals from 2 lines (19,20) were crossed mice carrying a floxed RBP-J allele to determine the activity of the cre transgene. Southern blot analysis of thymocytes from line #19 animals heterozygous for Rbpjtm1Hon showed complete deletion of the floxed locus.
(J:168475)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Lck
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:168475 Fu T, et al., Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice. Mol Immunol. 2011 Feb;48(5):751-9 |
| All: |
3 reference(s) |
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Analysis Tools
