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Hdac3tm1.1Laz
Targeted Allele Detail
Summary
Symbol: Hdac3tm1.1Laz
Name: histone deacetylase 3; targeted mutation 1.1, Mitchell A Lazar
MGI ID: MGI:4889069
Synonyms: HDAC3f, HDAC3flox
Gene: Hdac3  Location: Chr18:38070024-38088073 bp, - strand  Genetic Position: Chr18, 19.81 cM, cytoband B3
Alliance: Hdac3tm1.1Laz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168224
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 4 through 7 floxed. (J:178911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hdac3 Mutation:  33 strains or lines available
References
Original:  J:168224 McQuown SC, et al., HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci. 2011 Jan 12;31(2):764-74
All:  41 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory