Ren1tm1.1Sig
Targeted Allele Detail
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| Symbol: |
Ren1tm1.1Sig |
| Name: |
renin 1 structural; targeted mutation 1.1, Curt Sigmund |
| MGI ID: |
MGI:4939805 |
| Synonyms: |
sRENflox |
| Gene: |
Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
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| Alliance: |
Ren1tm1.1Sig page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:169129
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
C57BL/6J-Tyrc-2J
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1a (Ia). An additional loxP site was inserted downstream of exon 1a (Ia). Flp-mediated recombination removed the neo cassette leaving exon 1a (Ia) floxed.
(J:169129)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ren1 Mutation: |
35 strains or lines available
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ES cell = SCR (C57BL/6J-Tyrc-2J)
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| Original: |
J:169129 Xu D, et al., Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7 |
| All: |
4 reference(s) |
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Analysis Tools
