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Adgra2tm1.1Vlcg
Targeted Allele Detail
Summary
Symbol: Adgra2tm1.1Vlcg
Name: adhesion G protein-coupled receptor A2; targeted mutation 1.1, Velocigene
MGI ID: MGI:4940060
Synonyms: Gpr124Laz, Gpr124Lz
Gene: Adgra2  Location: Chr8:27575611-27613464 bp, + strand  Genetic Position: Chr8, 15.91 cM, cytoband A3
Alliance: Adgra2tm1.1Vlcg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169064
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Using VelociGene technology, most of the coding sequence (including exons 3 through 13) was replaced with a transmembrane domain lacZ and floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by northern blot analysis on embryo extracts. (J:102090, J:169064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 66 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adgra2 Mutation:  43 strains or lines available
References
Original:  J:169064 Anderson KD, et al., Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory