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Il17atm1.1(icre)Stck
Targeted Allele Detail
Summary
Symbol: Il17atm1.1(icre)Stck
Name: interleukin 17A; targeted mutation 1.1, Brigitta Stockinger
MGI ID: MGI:4940851
Synonyms: Il17aCre
Gene: Il17a  Location: Chr1:20801129-20804720 bp, + strand  Genetic Position: Chr1, 6.45 cM, cytoband A
Alliance: Il17atm1.1(icre)Stck page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169305
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Nucleotide substitutions
 
Il17atm1.1(icre)Stck expression driven by 1 gene
 
Mutation details: A codon-improved cre recombinase gene, preceded by a 5-codon linker sequence and followed by an SV40 intron and poly(A) signal sequences, was inserted immediately after the endogenous start codon in exon 1. Point mutations were introduced into exon 2 of the Il17a gene to disable an internal ATG-site. The neomycin resistance gene cassette that was inserted downstrea of the cre gene was excised by FLPe-mediated recombination to generate the the final allele. (J:169305)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il17a (mouse)
Summary of all recombinase alleles driven by Il17a.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il17a Mutation:  25 strains or lines available
References
Original:  J:169305 Hirota K, et al., Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol. 2011 Mar;12(3):255-63
All:  84 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory