Tg(Aqp2-cre/ERT2)4Gsc
Transgene Detail
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| Symbol: |
Tg(Aqp2-cre/ERT2)4Gsc |
| Name: |
transgene insertion 4, Gunther Schutz |
| MGI ID: |
MGI:4941815 |
| Synonyms: |
AQP2CreERT2 |
| Transgene: |
Tg(Aqp2-cre/ERT2)4Gsc Location: unknown
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| Alliance: |
Tg(Aqp2-cre/ERT2)4Gsc page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Aqp2-cre/ERT2)4Gsc expression driven by
1 gene
Transgene expression driven by:
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Mutation details: A genomic fragment of the murine Aqp2 gene in a PAC was modified by homologous recombination in bacterias to put the sequence for a cre/ERT2 fusion protein at the ATG site of the Aqp2 locus. This construct was microinjected into FVB/N pronuclei to produce transgenic animals. 3 lines with 1, 4, and 9 copies of the transgene were established and analyzed for cre expression. The lines show copy number-dependent quantitative differences but have identical expression profiles. The line with 4 copies was chosen for further studies.
(J:169670)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Aqp2
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:169670 Ronzaud C, et al., Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice. Am J Physiol Renal Physiol. 2011 Mar;300(3):F756-60 |
| All: |
1 reference(s) |
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Analysis Tools
