Gja5<tm2(cre/ERT2,RFP)Lumi> Targeted Allele Detail MGI Mouse (MGI:4941829)

Gja5^{tm2(cre/ERT2,RFP)Lumi}
Targeted Allele Detail

Summary

Symbol:	Gja5^{tm2(cre/ERT2,RFP)Lumi}
Name:	gap junction protein, alpha 5; targeted mutation 2, Lucile Miquerol
MGI ID:	MGI:4941829
Synonyms:	Cx40-CreERT2
Gene:	Gja5 Location: Chr3:96939718-96960950 bp, + strand Genetic Position: Chr3, 42.04 cM
Alliance:	Gja5^{tm2(cre/ERT2,RFP)Lumi} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:169695
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Gja5^{tm2(cre/ERT2,RFP)Lumi} expression driven by 1 gene

Mutation details: A cre/ERT2 cassette followed by an IRES::mRFP1 (monomeric RFP) sequence along with a PGK-neo cassette was introduced at the ATG site in exon 2 of the Gja5 locus, replacing the exon 2 sequence. (J:169695)

Generation of the Gja5^{tm2(cre/ERT2,RFP)Lumi} allele

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gja5 (mouse) Summary of all recombinase alleles driven by Gja5. Comparative matrix view of recombinase activities Alliance mouse Gja5 gene page

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gja5 Mutation:	19 strains or lines available

References

Original:	J:169695 Beyer S, et al., Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells. Genesis. 2011 Feb;49(2):83-91
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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