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Gene Expression Data
Assay Details
Assay
Reference: J:169064 Anderson KD, et al., Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12
Assay type: Immunohistochemistry
MGI Accession ID: MGI:4943929
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: horseradish peroxidase
Results
Specimen 3A: embryonic day 10.5; Adgra2tm1.1Vlcg/Adgra2+ (more )
Structure Level Pattern Image Note
TS17: forebrain vascular element Present 3A Expression is present in the perineural vascular plexus of the forebrain. There is also angiogenic sprouting in the ventral forebrain.
Specimen 3B: embryonic day 10.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS17: forebrain vascular element Present 3B As in wild type, expression is present in the perineural vascular plexus of the forebrain. However, unlike in wild type, there is no angiogenic sprouting in the ventral forebrain.
Specimen 3C: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2+ (more )
Structure Level Pattern Image Note
TS20: forebrain vascular element Present 3C
Specimen 3D: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: forebrain vascular element Present 3D Expression is present in vasculature of the forebrain, but it has an abnormal morphology in the mutant and the lateral pallium and the periventricular portion of the ganglionic eminences remain avascular.
Specimen 3F: embryonic day 10.5; Adgra2tm1.1Vlcg/Adgra2+ (more )
Structure Level Pattern Image Note
TS17: future spinal cord vascular element Present 3F Expression is present in the perineural vascular plexus of the spinal cord. There is angiogenic sprouting in the lateral aspects of the spinal cord.
Specimen 3G: embryonic day 10.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS17: future spinal cord vascular element Present 3G Expression is present in the perineural vascular plexus of the spinal cord. However, unlike in wild type, angiogenic sprouting is reduced in the dorsal spinal cord and absent in the ventral spinal cord.
Specimen 3H: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2+ (more )
Structure Level Pattern Image Note
TS20: spinal cord vascular element Present 3H
Specimen 3I: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: spinal cord vascular element Present 3I Expression is present in the vasculature of the spinal cord, but in the mutant vessel formation is abnormal.
Specimen S6 A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hypothalamus vascular element Present S6_A
Specimen S6 B: embryonic day 15.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS23: hypothalamus vascular element Present S6_B Expression is present in the vasculature of the hypothalamus, but the vessel density is much reduced in the mutant and shows abnormal morphology.
Specimen S6 C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex vascular element Present S6_C
Specimen S6 D: embryonic day 15.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS23: cerebral cortex vascular element Present S6_D Expression is present in the vasculature of the cerebral cortex, but in the mutant the vessels appear grossly aberrant and large regions of the cortex remain avascular.
Specimen S6 E: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung vascular element Present S6_E
Specimen S6 F: embryonic day 15.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS23: lung vascular element Present S6_F The vasculature in the mutant is indistinguishable from wild type.
Specimen S7 A: embryonic day 12.5 (more )
Note: Data for +/+ or +/- embryos were indistinguishable; thus the pictured specimen could have been a heterozygous animal.
Structure Level Pattern Image Note
TS20: midbrain vascular element Present S7_A
Specimen S7 B: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: midbrain vascular element Present S7_B The vasculature in the mutant is indistinguishable from wild type.
Specimen S7 C: embryonic day 12.5 (more )
Note: Data for +/+ or +/- embryos were indistinguishable; thus the pictured specimen could have been a heterozygous animal.
Structure Level Pattern Image Note
TS20: thalamus vascular element Present S7_C
Specimen S7 D: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: thalamus vascular element Present S7_D The vasculature in the mutant is indistinguishable from wild type.
Specimen S7 E: embryonic day 12.5 (more )
Note: Data for +/+ or +/- embryos were indistinguishable; thus the pictured specimen could have been a heterozygous animal.
Structure Level Pattern Image Note
TS20: stomach vascular element Present S7_E
Specimen S7 F: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: stomach vascular element Present S7_F The vasculature in the mutant is indistinguishable from wild type.
Specimen S7 G: embryonic day 12.5 (more )
Note: Data for +/+ or +/- embryos were indistinguishable; thus the pictured specimen could have been a heterozygous animal.
Structure Level Pattern Image Note
TS20: liver vascular element Present S7_G
Specimen S7 H: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: liver vascular element Present S7_H The vasculature in the mutant is indistinguishable from wild type.
Specimen S7 I: embryonic day 12.5 (more )
Note: Data for +/+ or +/- embryos were indistinguishable; thus the pictured specimen could have been a heterozygous animal.
Structure Level Pattern Image Note
TS20: tongue vascular element Present S7_I
Specimen S7 J: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Structure Level Pattern Image Note
TS20: tongue vascular element Present S7_J The vasculature in the mutant is indistinguishable from wild type.
Specimen S8 A: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Note: Double labeled: brown - Pecam1; blue - Adgra2 (assay MGI:4943905).
Structure Level Pattern Image Note
TS20: spinal cord vascular element Present S8_A Expression is present in the vasculature of the spinal cord, which is normal in the dorsal spinal cord and abnormal in the ventral spinal cord.
Specimen S8 B: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Note: Double labeled: brown - Pecam1; blue - Adgra2 (assay MGI:4943905).
Structure Level Pattern Image Note
TS20: spinal cord vascular element Present S8_B Expression is present in the vasculature of the ganglionic eminence.
Specimen S8 C: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Note: Double labeled: brown - Pecam1; blue - Adgra2 (assay MGI:4943905).
Structure Level Pattern Image Note
TS20: arterial system Present S8_C Expression is present in the carotid.
Specimen S8 D: embryonic day 12.5; Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg (more )
Note: Double labeled: brown - Pecam1; blue - Adgra2 (assay MGI:4943905).
Structure Level Pattern Image Note
TS20: forebrain vascular element Present S8_D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory