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Lrig1tm1.1(cre/ERT2)Rjc
Targeted Allele Detail
Summary
Symbol: Lrig1tm1.1(cre/ERT2)Rjc
Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1.1, Robert J Coffey
MGI ID: MGI:4947937
Synonyms: Lrig1-CreERT2
Gene: Lrig1  Location: Chr6:94581510-94677139 bp, - strand  Genetic Position: Chr6, 43.15 cM
Alliance: Lrig1tm1.1(cre/ERT2)Rjc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186084
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Lrig1tm1.1(cre/ERT2)Rjc expression driven by 1 gene
 
Mutation details: The targeting vector used for homologous recombination was generated by BAC recombineering. A tamoxifen-inducible cre (cre/ERT2) sequence, SV40 polyA signal, and an Frt-flanked PGK-neo cassette were targeted to the endogenous ATG site of Lrig1. Chimeras were crossed with Flpe-expressing animals to remove the neo from the germline. (J:186084)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lrig1 (mouse)
Summary of all recombinase alleles driven by Lrig1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Lrig1tm1.1(cre/ERT2)Rjc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrig1 Mutation:  50 strains or lines available
References
Original:  J:186084 Powell AE, et al., The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 2012 Mar 30;149(1):146-58
All:  43 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory