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Kcnu1tm1.2Clin
Targeted Allele Detail
Summary
Symbol: Kcnu1tm1.2Clin
Name: potassium channel, subfamily U, member 1; targeted mutation 1.2, Christopher J Lingle
MGI ID: MGI:4949763
Gene: Kcnu1  Location: Chr8:26339651-26427967 bp, + strand  Genetic Position: Chr8, 14.17 cM, cytoband A3
Alliance: Kcnu1tm1.2Clin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171225
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Cre-mediated recombination removed exon 27, the EGFP, and the neo cassette. The absence of protein expression was confirmed by western blot analysis on testes extracts. (J:171225)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnu1 Mutation:  63 strains or lines available
References
Original:  J:171225 Zeng XH, et al., Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5879-84
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory