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Rhoatm1Jrel
Targeted Allele Detail
Summary
Symbol: Rhoatm1Jrel
Name: ras homolog family member A; targeted mutation 1, Joao B Relvas
MGI ID: MGI:4950374
Synonyms: Rholox
Gene: Rhoa  Location: Chr9:108183359-108215142 bp, + strand  Genetic Position: Chr9, 59.2 cM
Alliance: Rhoatm1Jrel page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171199
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette. (J:171199, J:182206)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhoa Mutation:  73 strains or lines available
References
Original:  J:171199 Herzog D, et al., The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool. J Neurosci. 2011 Mar 30;31(13):5120-5130
All:  25 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory