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Myoctm3(cre/ERT2)Rjo
Targeted Allele Detail
Summary
Symbol: Myoctm3(cre/ERT2)Rjo
Name: myocilin; targeted mutation 3, Randy L Johnson
MGI ID: MGI:4950391
Synonyms: Myoc-CreER(T2)
Gene: Myoc  Location: Chr1:162466724-162477262 bp, + strand  Genetic Position: Chr1, 70.29 cM
Alliance: Myoctm3(cre/ERT2)Rjo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171549
Parent Cell Line:  RJ2.2 (ES Cell)
Strain of Origin:  (C57BL/6Brd-Tyrc-Brd x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Myoctm3(cre/ERT2)Rjo expression driven by 1 gene
 
Mutation details: A targeting vector was constructed so that homology arms flanked a cassette containing an IRES-cre/ERT2-pA-neo-loxP-pA sequence. Homologous recombination in RJ2.2 ES cells resulted in insertion of the cassette into the 3' UTR of the Myoc locus. (J:171549)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myoc (mouse)
Summary of all recombinase alleles driven by Myoc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myoc Mutation:  27 strains or lines available
References
Original:  J:171549 Liu P, et al., Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 Feb;52(2):969-74
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/19/2024
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