Cd151<tm2Nki> Targeted Allele Detail MGI Mouse (MGI:4950443)

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Cd151^tm2Nki
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cd151^tm2Nki
Name:	CD151 antigen; targeted mutation 2, The Netherlands Cancer Institute
MGI ID:	MGI:4950443
Synonyms:	Cd151^fl, Cd151^tm2Son
Gene:	Cd151 Location: Chr7:141047305-141051386 bp, + strand Genetic Position: Chr7, 86.82 cM
Alliance:	Cd151^tm2Nki page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:205736
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. This allele was used to generate Cd151^tm1Nki. (J:114988)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cd151 Mutation:	34 strains or lines available

References

Original:	J:114988 Sachs N, et al., Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol. 2006 Oct 9;175(1):33-9
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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