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Ins2tm1(cre/ERT2)Kcmm
Targeted Allele Detail
Summary
Symbol: Ins2tm1(cre/ERT2)Kcmm
Name: insulin II; targeted mutation 1, Susumu Seino
MGI ID: MGI:4950476
Synonyms: Ins2-CreERT2
Gene: Ins2  Location: Chr7:142232393-142233463 bp, - strand  Genetic Position: Chr7, 88.0 cM
Alliance: Ins2tm1(cre/ERT2)Kcmm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171567
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Ins2tm1(cre/ERT2)Kcmm expression driven by 1 gene
 
Mutation details: A cre/ERT2 cassette was inserted into the ATG site in exon2 of the mouse Ins2 gene by homologous recombination, replacing exons 2 and 3. Expression of cre recombinase was only detected in insulin-expressing beta cells. (J:171567)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ins2 (mouse)
Summary of all recombinase alleles driven by Ins2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ins2 Mutation:  93 strains or lines available
References
Original:  J:171567 Nakamura K, et al., Pancreatic beta-cells are generated by neogenesis from non-beta-cells after birth. Biomed Res. 2011;32(2):167-74
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory