Creb1<tm3.1Gsc> Targeted Allele Detail MGI Mouse (MGI:4999627)

Creb1^tm3.1Gsc
Targeted Allele Detail

Summary

Symbol:	Creb1^tm3.1Gsc
Name:	cAMP responsive element binding protein 1; targeted mutation 3.1, Gunther Schutz
MGI ID:	MGI:4999627
Synonyms:	Creb1^-
Gene:	Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance:	Creb1^tm3.1Gsc page

Lung development abnormalities in Creb1^tm3.1Gsc/Creb1^tm3.1Gsc mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:171712
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A single loxP site was inserted 5' to exon 10 and a loxP flanked neomycin and thymidine kinase cassette was inserted 3' to exon 10. Cre mediated recombination removed the selection cassette and exon 10. (J:76211, J:171712)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	37 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Creb1 Mutation:	61 strains or lines available

References

Original:	J:171712 Bird AD, et al., cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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