Ndrg1<str> Spontaneous Allele Detail MGI Mouse (MGI:5009138)

Ndrg1^str
Spontaneous Allele Detail

Summary

Symbol:	Ndrg1^str
Name:	N-myc downstream regulated gene 1; stretcher
MGI ID:	MGI:5009138
Synonyms:	str
Gene:	Ndrg1 Location: Chr15:66801167-66841489 bp, - strand Genetic Position: Chr15, 29.3 cM, cytoband D3
Alliance:	Ndrg1^str page

Mutation
origin

Strain of Origin:

NOD/ShiLtJWehi

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion
		Mutation details: More than 5 kilobase pairs of DNA encompassing exons 10-14 have been deleted. Northern blot analysis of kidney RNA reveals the presence in mutant mice of a shorter than normal mRNA, at levels similar to those of the normal transcript in wild-typie littermates; the cDNA sequence confirms that the mutant mRNA has exon 9 spliced in-frame to exon 15. Western blot analysis of protein extracts from sciatic nerve with antibodies to full-length NDRG1 reveals an intense 43-kDa band in wild-type and a very faint band of 32 kDa in mutant sciatic nerve. (J:172770, J:198695)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Ndrg1 Mutation:	29 strains or lines available

Notes

The mutant phenotype was observed during production of the NOD.B6-Slc9a1^b/Gem (Chr 4; J:60311) congenic strain. Fine-mapping analysis employing simple sequence length polymorphisms (SSLPs) differentiating NOD, C57BL/6 and DBA/2 (the second parental strain in the mapping cross) demonstrated that the mutation had occurred in a segment of Chr 15 derived from NOD. (J:198695)

References

Original:	J:198695 Chandler D, et al., The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D [v1; ref status: indexed, http://f1000r.es/8c]. F1000Res. 2013;2
All:	3 reference(s)

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