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Notch1tm4(cre)Rko
Targeted Allele Detail
Summary
Symbol: Notch1tm4(cre)Rko
Name: notch 1; targeted mutation 4, Raphael Kopan
MGI ID: MGI:5009236
Synonyms: N1::Crehi, NIP::CreHI, Notch1::creHi
Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM
Alliance: Notch1tm4(cre)Rko page
Embryonic lethality in Notch1tm2Rko/Notch1tm4(cre)Rko embryos due to the failure of angiogenic remodeling

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171829
Parent Cell Line:  SCC10 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Notch1tm4(cre)Rko expression driven by 1 gene
 
Mutation details: The Notch1 intracellular domain (IC) is replaced by the cre recombinase sequence and includes the SV40 3' UTR polyA signal while introducing a single nucleotide variation (SNV) at C5178A to facilitate genotyping. This allele does not have the 6xMyc tag present in the Notch1tm3(cre)Rko allele, and displays enhanced activity relative to that allele. (J:171829, J:172930)
Generation of the Notch1tm4(cre)Rko allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Notch1 (mouse)
Summary of all recombinase alleles driven by Notch1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  117 strains or lines available
References
Original:  J:171829 Liu Z, et al., Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011 Feb 1;121(2):800-8
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory