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Shox2tm2(SHOX_a)Ypc
Targeted Allele Detail
Summary
Symbol: Shox2tm2(SHOX_a)Ypc
Name: SHOX homeobox 2; targeted mutation 2, YiPing Chen
MGI ID: MGI:5009257
Synonyms: Shox2KI+Neo
Gene: Shox2  Location: Chr3:66879060-66889104 bp, - strand  Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
Alliance: Shox2tm2(SHOX_a)Ypc page
Small size of Shox2tm2(SHOX_a)Ypc/Shox2tm2(SHOX_a)Ypc pups

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172674
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1 and 2, including the start codon, were replaced with a full length human SHOX_a cDNA and an FRT flanked neo cassette via homologous recombination. RT_PCR analysis indicates that the presence of the neo cassette reduced expression of the human gene compared to mice with the neo cassette deleted. (J:172674)
Generation of the Shox2tm2(SHOX_a)Ypc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shox2 Mutation:  20 strains or lines available
References
Original:  J:172674 Liu H, et al., Functional Redundancy between Human SHOX and Mouse Shox2 Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function. J Biol Chem. 2011 May 13;286(19):17029-38
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory