Tg(Igh-15B3Vh/Ighm*a)502Zbz
Transgene Detail
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| Symbol: |
Tg(Igh-15B3Vh/Ighm*a)502Zbz |
| Name: |
transgene insertion 502, Universitatsspital Zurich, Biologisches Zentrallaboratorium |
| MGI ID: |
MGI:5014186 |
| Synonyms: |
15B3mu, Tg(15B3)502, TgN(15B3IgH)502Zbz |
| Transgene: |
Tg(Igh-15B3Vh/Ighm*a)502Zbz Location: unknown
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| Alliance: |
Tg(Igh-15B3Vh/Ighm*a)502Zbz page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Igh-15B3Vh/Ighm*a)502Zbz expresses
2 genes
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Mutation details: This transgene encodes an immunoglobulin heavy chain (IgH) whose variable region is that of the monoclonal antibody expressed by the 15B3 hybridoma cell line, which recognizes the scrapie prion protein (PRNPSc); this is joined to the mu constant region (Cu) of the Igha haplotype. Transgenic mice express antibodies composed of transgene-derived IgMa mu heavy chains paired with various endogenously encoded immunoglobulin kappa and lambda light chains, but have no detectable IgHM/D from endogenous genes. Antisera from these mice do not exhibit anti-PRNP activity.
(J:127850)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:127850 Heppner FL, et al., Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science. 2001 Oct 5;294(5540):178-82 |
| All: |
1 reference(s) |
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Analysis Tools
