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Six1tm1(cre)Xli
Targeted Allele Detail
Summary
Symbol: Six1tm1(cre)Xli
Name: sine oculis-related homeobox 1; targeted mutation 1, Xue Li
MGI ID: MGI:5014213
Synonyms: Six1Cre-hpAP, Six1Cre/hpAP, Six1hpAP/Cre, Six1tm1(cre,ALPP)Xli
Gene: Six1  Location: Chr12:73088601-73093486 bp, - strand  Genetic Position: Chr12, 30.34 cM
Alliance: Six1tm1(cre)Xli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172023
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Six1tm1(cre)Xli expression driven by 1 gene
 
Mutation details: A partial Six1 coding sequence was replaced by homologous recombination with the cre-ALPP (human placenta alkaline phosphatase) sequence linked to an internal ribosomal entry site (IRES)) dicistronic reporter and a PGK-neo selection gene. The allele is a functionally-null allele. (J:172023, J:178455)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Six1 (mouse)
Summary of all recombinase alleles driven by Six1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 34 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six1 Mutation:  19 strains or lines available
References
Original:  J:172023 Guo C, et al., A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory