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Msx1tm2.1(cre/ERT2)Bero
Targeted Allele Detail
Summary
Symbol: Msx1tm2.1(cre/ERT2)Bero
Name: msh homeobox 1; targeted mutation 2.1, Benoit Robert
MGI ID: MGI:5049923
Synonyms: Msx1-CreERT2, Msx1CreERT2, Msx1tm2(cre/ERT2)Bero
Gene: Msx1  Location: Chr5:37977835-37981929 bp, - strand  Genetic Position: Chr5, 20.21 cM
Alliance: Msx1tm2.1(cre/ERT2)Bero page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173525
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Msx1tm2.1(cre/ERT2)Bero expression driven by 1 gene
 
Mutation details: A targeting vector with the cre/ERT2 sequence, polyadenylation site, and an Frt-flanked neomycin cassette inserted into the ATG site of Msx1 in a plasmid was generated by homologous recombination in bacteria. The linearized targeting vector was electroporated into ES cells and targeted clones were used to generated chimeras. F1 offspring were crossed to Flp deleter mice to delete the neo marker. (J:173525, J:194129)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Msx1 (mouse)
Summary of all recombinase alleles driven by Msx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Msx1 Mutation:  18 strains or lines available
References
Original:  J:173525 Lopes M, et al., Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development. 2011 Jul;138(14):3055-66
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory