Tg(JPH3*)CXwy Transgene Detail MGI Mouse (MGI:5052363)

Tg(JPH3*)CXwy
Transgene Detail

Summary

Symbol:	Tg(JPH3*)CXwy
Name:	transgene insertion C, X William Yang
MGI ID:	MGI:5052363
Synonyms:	BAC-HDL2
Transgene:	Tg(JPH3*)CXwy Location: unknown
Alliance:	Tg(JPH3*)CXwy page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(JPH3*)CXwy expresses 1 gene

Mutation details: The human BAC (RP11-33A21) was modified to include an expanded CTG/CAG track of 120 repeats in exon 2A of JPH3. This line has a single integration of the transgene with 116 CTG/CAG repeats. RT-PCR analysis indicates the level of overexpression of the transgene was about 100% of the endogenous gene. (J:174267)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

Original:	J:174267 Wilburn B, et al., An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice. Neuron. 2011 May 12;70(3):427-40
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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