Casp3<hith2> Chemically induced Allele Detail MGI Mouse (MGI:5056374)

Casp3^hith2
Chemically induced Allele Detail

Summary

Symbol:	Casp3^hith2
Name:	caspase 3; hole in the head 2
MGI ID:	MGI:5056374
Gene:	Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
Alliance:	Casp3^hith2 page

Mutation
origin

Strain of Origin:

A/J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Nucleotide substitutions
		Mutation details: Identified in an ENU screen and mapped to a 4 Mb interval on Chromosome 8 containing Casp3. A mutation two bases upstream of exon 3 results in splicing errors causing exon 3 splicing to be 4 nucleotides into the wild type exon or loss of exon 3 altogether. Both forms result in premature stop codons. (J:174027)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Casp3 Mutation:	33 strains or lines available

References

Original:	J:174027 Stottmann RW, et al., Focusing Forward Genetics: A Tripartite ENU Screen for Neurodevelopmental Mutations in the Mouse. Genetics. 2011 Jul;188(3):615-24
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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