About   Help   FAQ
Trp63tm1Sin
Targeted Allele Detail
Summary
Symbol: Trp63tm1Sin
Name: transformation related protein 63; targeted mutation 1, Satrajit Sinha
MGI ID: MGI:5140823
Synonyms: deltaNp63GFP
Gene: Trp63  Location: Chr16:25502513-25710842 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance: Trp63tm1Sin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173538
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: An EGFP gene was fused in frame to the codon specific for the delta N isoform and an FRT flanked neo cassette was inserted via homologous recombination. Homozygous mice do not express the deltaN isoform but retain expression of the TA isoform. GFP expression mirrors that of the endogenous protein. (J:173538, J:181275)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  60 strains or lines available
References
Original:  J:173538 Packard A, et al., {Delta}Np63 regulates stem cell dynamics in the Mammalian olfactory epithelium. J Neurosci. 2011 Jun 15;31(24):8748-59
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory