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Slc17a6tm2(cre)Lowl
Targeted Allele Detail
Summary
Symbol: Slc17a6tm2(cre)Lowl
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 2, Bradford B Lowell
MGI ID: MGI:5141269
Synonyms: Vglut2Cre, Vglut2-ires-Cre
Gene: Slc17a6  Location: Chr7:51271754-51320867 bp, + strand  Genetic Position: Chr7, 32.78 cM, cytoband B4
Alliance: Slc17a6tm2(cre)Lowl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174691
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Slc17a6tm2(cre)Lowl expression driven by 1 gene
 
Mutation details: A targeting vector, constructed from a BAC clone containing the Slc17a6 (Vglut2) gene, was utilized to insert an internal ribosomal entry site followed by the cre recombinase sequence and an frt-flanked kanamycin/neomycin (kan/neo) resistance cassette into the Slc17a6 locus just downstream of the endogenous stop codon. Cre is expressed from the Slc17a6 gene promoter. (J:174691)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc17a6 (mouse)
Summary of all recombinase alleles driven by Slc17a6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Slc17a6 Mutation:  60 strains or lines available
References
Original:  J:174691 Vong L, et al., Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. 2011 Jul 14;71(1):142-54
All:  511 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory