Pax7<tm1(cre/ERT2)Gaka> Targeted Allele Detail MGI Mouse (MGI:5141477)

Pax7^{tm1(cre/ERT2)Gaka}
Targeted Allele Detail

Summary

Symbol:	Pax7^{tm1(cre/ERT2)Gaka}
Name:	paired box 7; targeted mutation 1, Gabrielle Kardon
MGI ID:	MGI:5141477
Gene:	Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
Alliance:	Pax7^{tm1(cre/ERT2)Gaka} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:174914
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Pax7^{tm1(cre/ERT2)Gaka} expression driven by 1 gene

Mutation details: An IRES-cre/ERT2 and an FRT flanked neomycin selection cassette were inserted 8 bp after the endogenous stop codon. The selection cassette was subsequently removed by crossing to a Gt(ROSA)26Sor^tm1(FLP1)Dym mouse line. Endogenous gene function is preserved. (J:174914)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax7 (mouse) Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities Alliance mouse Pax7 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Pax7 Mutation:	38 strains or lines available

References

Original:	J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
All:	98 reference(s)

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