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Tcf7l2tm3.1(cre/ERT2)Mrc
Targeted Allele Detail
Summary
Symbol: Tcf7l2tm3.1(cre/ERT2)Mrc
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 3.1, Mario R Capecchi
MGI ID: MGI:5141491
Synonyms: Tcf4CreERT2
Gene: Tcf7l2  Location: Chr19:55730252-55922086 bp, + strand  Genetic Position: Chr19, 51.59 cM
Alliance: Tcf7l2tm3.1(cre/ERT2)Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174914
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Tcf7l2tm3.1(cre/ERT2)Mrc expression driven by 1 gene
 
Mutation detailsThe translated part of exon 1 was replaced by a cre/ERT2 cassette and a GCSF polyA signal. An FRT-flanked neomycin resistance (neo) cassette was inserted downstream of the creERT2 fusion gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:174914)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tcf7l2 (mouse)
Summary of all recombinase alleles driven by Tcf7l2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  58 strains or lines available
Notes
ES cell line = R1-45, established from (129X1/SvJ x 129S1/Sv)F1-Kitl+
References
Original:  J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory