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Cdk6tm2.1Phin
Targeted Allele Detail
Summary
Symbol: Cdk6tm2.1Phin
Name: cyclin dependent kinase 6; targeted mutation 2.1, Philip Hinds
MGI ID: MGI:5141514
Synonyms: Cdk6R31C
Gene: Cdk6  Location: Chr5:3391485-3581008 bp, + strand  Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
Alliance: Cdk6tm2.1Phin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174697
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of cystine for arginine at position 31 (R31C). A floxed stop cassette downstream of the modified exon 1 that prevents expression was removed by cre-mediated recombination. The product is predicted to be a hyperactivate kinase. (J:174697)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk6 Mutation:  40 strains or lines available
References
Original:  J:174697 Hu MG, et al., CDK6 kinase activity is required for thymocyte development. Blood. 2011 Jun 9;117(23):6120-31
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory