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Gene Expression Data
Assay Details
Assay
Reference: J:72238 Boulter C, et al., Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12174-9
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5142248
Gene symbol: Pkd1
Gene name: polycystin 1, transient receptor potential channel interacting
Reporter: lacZ
Direct Detection
Results
Specimen 2c: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: nephron Weak 2c Expression is present throughout (except in podocytes).
TS28: medullary collecting duct Present 2c
TS28: papillary duct Present 2c
TS28: renal vasculature Present 2c
TS28: ureter Present 2c
Specimen 2d: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: medullary collecting duct Present 2d
Specimen 2e: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: parietal epithelium of mature renal corpuscle Present 2e
TS28: renal distal tubule Present Regionally restricted 2e Expression is present in the epithelium.
TS28: renal proximal tubule Present Regionally restricted 2e Expression is present in the epithelium.
TS28: afferent arteriole of mature renal corpuscle Strong 2e
Specimen 2g: embryonic day 13.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS21: mesenchyme of metanephros Weak 2g Expression is present in induced and uninduced mesenchyme.
TS21: comma-shaped body Absent 2g
TS21: s-shaped body Absent 2g
Specimen 2h: embryonic day 15.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS23: mesenchyme of metanephros Present 2h
TS23: renal tubule Present 2h Expression is present in the maturing tubules of the nephron and collecting duct system.
TS23: s-shaped body Absent 2h
Specimen 2i: embryonic day 15.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS23: mesenchyme of metanephros Present 2i
TS23: renal tubule Present 2i Expression is present in the maturing tubules of the nephron and collecting duct system.
Specimen 2j: embryonic day 18.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS26: mesenchyme of metanephros Present 2j
TS26: renal tubule Present 2j Expression is present in the maturing tubules of the nephron and collecting duct system.
Specimen 3a: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: pancreatic duct Weak 3a
TS28: bile duct Weak 3a Expression is present in the intrahepatic bile duct.
TS28: liver parenchyma Absent 3a There is no expression in the hepatocytes.
Specimen 3a inset: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: gallbladder Present 3a inset
Specimen 3b: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: aorta Strong 3b Expression is present in the aortic outflow tract.
TS28: heart atrium Strong Regionally restricted 3b Expression is present in the atrial appendages.
TS28: heart blood vessel Strong Regionally restricted 3b Expression is present in major coronary vessels.
TS28: bronchus Present 3b
TS28: lung vascular element Present 3b
TS28: trachea cartilage Present 3b
Specimen 3c: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: aorta Present 3c
Specimen 3c inset: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: aorta endothelium Present 3c inset
TS28: aorta smooth muscle Present 3c inset
Specimen 3d: postnatal adult; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Present 3d Expression is present in the intracranial arteries.
Specimen Not shown: embryonic day 9.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS15: dorsal aorta Present
Specimen Not shown: embryonic day 10.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS17: heart Present Expression is present in all structures of the heart.
Specimen 3e: embryonic day 14.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS22: dorsal aorta Present 3e
TS22: intervertebral disc Present 3e
TS22: vertebral cartilage condensation Present 3e
TS22: blood vessel Present 3e Expression is present in all major vessels.
Specimen 3f: embryonic day 18.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS26: cardiovascular system Present 3f Expression is present in the cardiac outflow tract.
TS26: endocardial cushion Present 3f
TS26: cardiac valve leaflet Present 3f
TS26: cardiac muscle tissue Present 3f
Specimen 3h: embryonic day 11.5; Pkd1tm1Rsa/Pkd1+ (more )
Structure Level Pattern Image Note
TS19: neural tube floor plate Present 3h
TS19: notochord Present 3h
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory