Opn4<tm2.1(cre/ERT2)Saha> Targeted Allele Detail MGI Mouse (MGI:5285845)

Opn4^{tm2.1(cre/ERT2)Saha}
Targeted Allele Detail

Summary

Symbol:	Opn4^{tm2.1(cre/ERT2)Saha}
Name:	opsin 4 (melanopsin); targeted mutation 2.1, Samer Hattar
MGI ID:	MGI:5285845
Synonyms:	Opn4^CreERT2
Gene:	Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
Alliance:	Opn4^{tm2.1(cre/ERT2)Saha} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:174940
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Opn4^{tm2.1(cre/ERT2)Saha} expression driven by 1 gene

Mutation details: The targeting arms and same general strategy used to produce the Opn4^tm1(cre)Saha allele (MGI:4881482) was employed to generate this allele. Differences are that the targeting construct contained the rabbit beta-globin intron, the cre/ERT2 sequence, and an IRES-lacZ cassette downstream of the melanopsin (Opn4) start codon. (J:167871, J:174940)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Opn4 (mouse) Summary of all recombinase alleles driven by Opn4. Alliance mouse Opn4 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Opn4 Mutation:	33 strains or lines available

References

Original:	J:174940 Chen SK, et al., Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature. 2011 Aug 4;476(7358):92-5
All:	9 reference(s)

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