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Ppp2r1atm1.1Wltr
Targeted Allele Detail
Summary
Symbol: Ppp2r1atm1.1Wltr
Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 1.1, Gernot Walter
MGI ID: MGI:5287252
Synonyms: PP2A-A-alpha-floxed5-6 (F5-6)
Gene: Ppp2r1a  Location: Chr17:21165716-21186167 bp, + strand  Genetic Position: Chr17, 11.4 cM, cytoband A3.2
Alliance: Ppp2r1atm1.1Wltr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175748
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 5, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:175748)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp2r1a Mutation:  41 strains or lines available
References
Original:  J:175748 Ruediger R, et al., Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol. 2011 Sep;31(18):3832-44
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory