Inca1<tm1Cmt> Targeted Allele Detail MGI Mouse (MGI:5292392)

Inca1^tm1Cmt
Targeted Allele Detail

Summary

Symbol:	Inca1^tm1Cmt
Name:	inhibitor of CDK, cyclin A1 interacting protein 1; targeted mutation 1, Carsten Muller-Tidow
MGI ID:	MGI:5292392
Gene:	Inca1 Location: Chr11:70579187-70590981 bp, - strand Genetic Position: Chr11, 43.21 cM
Alliance:	Inca1^tm1Cmt page

Disruption of splenic architecture in Inca1^tm1Cmt/Inca1^tm1Cmt mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:175667
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 3 through 7 were replaced with an IRES, lacZ, and floxed neo cassette. The absence of transcript expression was confirmed by RT-PCR on mouse embryonic fibroblasts, testis, liver, kidney, and lung extracts. (J:175667)

Generation of the Inca1^tm1Cmt allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Inca1 Mutation:	15 strains or lines available

References

Original:	J:175667 Baumer N, et al., Inhibitor of Cyclin-dependent Kinase (CDK) Interacting with Cyclin A1 (INCA1) Regulates Proliferation and Is Repressed by Oncogenic Signaling. J Biol Chem. 2011 Aug 12;286(32):28210-22
All:	3 reference(s)

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