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Capn2tm2.1Tcs
Targeted Allele Detail
Summary
Symbol: Capn2tm2.1Tcs
Name: calpain 2; targeted mutation 2.1, Takaomi C Saido
MGI ID: MGI:5292735
Synonyms: Capn2flox
Gene: Capn2  Location: Chr1:182294825-182345173 bp, - strand  Genetic Position: Chr1, 84.93 cM
Alliance: Capn2tm2.1Tcs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175868
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A floxed neo cassette was inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 3 floxed. (J:175868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Capn2 Mutation:  35 strains or lines available
References
Original:  J:175868 Takano J, et al., Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct;31(19):4097-106
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory