Mir34a<tm1Hher> Targeted Allele Detail MGI Mouse (MGI:5293762)

Mir34a^tm1Hher
Targeted Allele Detail

Summary

Symbol:	Mir34a^tm1Hher
Name:	microRNA 34a; targeted mutation 1, Heiko Hermeking
MGI ID:	MGI:5293762
Gene:	Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
Alliance:	Mir34a^tm1Hher page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:175978
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of the microRNA. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the microRNA. The neo cassette was removed via flp-mediated recombination and the floxed microRNA deleted via cre-mediated recombination. This allele was generated from Mir34a^tm2.1Hher. (J:209587)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Mir34a^tm1Hher

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mir34a Mutation:	9 strains or lines available

References

Original:	J:175978 Hwang CI, et al., Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14240-5
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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