Cd8a<tm1.1(cre)Koni> Targeted Allele Detail MGI Mouse (MGI:5294414)

Cd8a^{tm1.1(cre)Koni}
Targeted Allele Detail

Summary

Symbol:	Cd8a^{tm1.1(cre)Koni}
Name:	CD8 subunit alpha; targeted mutation 1.1, Pandelakis A Koni
MGI ID:	MGI:5294414
Synonyms:	Cd8acre
Gene:	Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
Alliance:	Cd8a^{tm1.1(cre)Koni} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:177182
Parent Cell Line:	LK-1/LK1 (ES Cell)
Strain of Origin:	C57BL/6NHsd

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Cd8a^{tm1.1(cre)Koni} expression driven by 1 gene

Mutation details: A targeting vector was designed to insert a cre-recombinase coding sequence, a neomycin resistance cassette, and an internal ribosome entry site (IRES) into the start codon of the CD8 antigen alpha chain (Cd8a) gene. The construct was electroporated into C57BL/6NHsd-derived LK1 embryonic stem (ES) cells. Chimeras were bred to C57BL/6 animals. Offspring were crossed to Flp-expressing mice to delete the neo cassette. (J:177182)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd8a (mouse) Summary of all recombinase alleles driven by Cd8a. Alliance mouse Cd8a gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cd8a Mutation:	39 strains or lines available

References

Original:	J:177182 Koni PA, Generation of a cre knock-in allele at the Cd8a locus. MGI Direct Data Submission. 2011;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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