Cdh5<tm3(Cdh5/Ctnna1)Dvst> Targeted Allele Detail MGI Mouse (MGI:5294790)

Cdh5^{tm3(Cdh5/Ctnna1)Dvst}
Targeted Allele Detail

Summary

Symbol:	Cdh5^{tm3(Cdh5/Ctnna1)Dvst}
Name:	cadherin 5; targeted mutation 3, Dietmar Vestweber
MGI ID:	MGI:5294790
Synonyms:	VEC-alpha-C
Gene:	Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
Alliance:	Cdh5^{tm3(Cdh5/Ctnna1)Dvst} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:177191
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted
Mutations:		Insertion, Intragenic deletion
		Mutation details: RMCE replaced exon 2 and the neo cassette in Cdh5^tm1Dvst with a fusion of mouse Cdh5 lacking 75 C-terminal amino acids of the cytoplasmic tail and the C-terminal two-thirds of mouse alpha-catenin (amino acids 301-900), transcription stop sequence, and FRT-flanked hygro flanked by a loxP and a lox2272 site. A C to T mutation was inserted 2130 bp from the start codon to create a new ClaI site. (J:177191)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:	59 strains or lines available

Notes

This allele was generated from Cdh5^tm1Dvst.

References

Original:	J:177191 Schulte D, et al., Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 2011;30(20):4157-70
All:	3 reference(s)

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