Cdh5<tm1Dvst> Targeted Allele Detail MGI Mouse (MGI:5294807)

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Cdh5^tm1Dvst
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Summary

Symbol:	Cdh5^tm1Dvst
Name:	cadherin 5; targeted mutation 1, Dietmar Vestweber
MGI ID:	MGI:5294807
Gene:	Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
Alliance:	Cdh5^tm1Dvst page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:189010
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change, RMCE-ready)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2. A neo cassette with a 3' lox2272 was inserted downstream of exon 2. (J:177191)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:	59 strains or lines available

Notes

This allele was used to generate: Cdh5^{tm2(Cdh5)Dvst},Cdh5^{tm3(Cdh5/Ctnna1)Dvst}, Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst}, Cdh5^tm5Dvst, Cdh5^tm6Dvst, Cdh5^tm7Dvst, Cdh5^tm8Dvst, Cdh5^tm9Dvst.

References

Original:	J:177191 Schulte D, et al., Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 2011;30(20):4157-70
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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