Sox2<tm1(cre/ERT2)Hoch> Targeted Allele Detail MGI Mouse (MGI:5295990)

Sox2^{tm1(cre/ERT2)Hoch}
Targeted Allele Detail

Summary

Symbol:	Sox2^{tm1(cre/ERT2)Hoch}
Name:	SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger
MGI ID:	MGI:5295990
Synonyms:	Sox2-Cre^ER
Gene:	Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2^{tm1(cre/ERT2)Hoch} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:177655
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Sox2^{tm1(cre/ERT2)Hoch} expression driven by 1 gene

Mutation details: A targeting construct encoding a cre recombinase/mutated estrogen ligand binding-domain (cre/ERT2) fusion sequence and an Frt-flanked neo cassette was targeted to the Sox2 locus in V6.5 ES cells, so that cre was under control of endogenous Sox2 regulatory elements. Chimeric mice were bred to 129/SvJae wild-type animals to test for germline transmission and to establish stable lines. (J:177655)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

References

Original:	J:177655 Arnold K, et al., Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29
All:	126 reference(s)

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